Male-to-female transsexuals show sex-atypical hypothalamus activation when smelling odorous steroids

Year Published: 2008

Published In: Cerebral Cortex

Sample: 12 trans-women (identified as being attracted to women, although the paper chooses to use the term nonhomosexual)

Conclusion: "Like in female controls the hypothalamus in MFTRs activated with AND, whereas smelling of EST engaged the amygdala and piriform cortex. Male controls, on the other hand, activated the hypothalamus with EST. However, when restricting the volume of interest to the hypothalamus activation was detected in MFTR also with EST, and explorative conjunctional analysis revealed that MFTR shared a hypothalamic cluster with women when smelling AND, and with men when smelling EST. Because the EST effect was limited, MFTR differed significantly only from male controls, and only for EST-AIR and EST-AND. These data suggest a pattern of activation away from the biological sex, occupying an intermediate position with predominantly female-like features. Because our MFTRs were nonhomosexual, the results are unlikely to be an effect of sexual practice. Instead, the data implicate that transsexuality may be associated with sex-atypical physiological responses in specific hypothalamic circuits, possibly as a consequence of a variant neuronal differentiation."

DOI: 10.1093/cercor/bhm216

Fulltext: Male-to-female transsexuals show sex-atypical hypothalamus activation when smelling odorous steroids

Citation: Berglund, H., P. Lindstrom, C. Dhejne-Helmy, and I. Savic. "Male-to-Female Transsexuals Show Sex-Atypical Hypothalamus Activation When Smelling Odorous Steroids." Cerebral Cortex 18.8 (2008): 1900-908.

Authors

Cited By ( 1 )

Raw Bibtex

@article{berglund2008male,
  title={Male-to-female transsexuals show sex-atypical hypothalamus activation when smelling odorous steroids},
  author={Berglund, H and Lindstrom, P and Dhejne-Helmy, C and Savic, I},
  journal={Cerebral Cortex},
  volume={18},
  number={8},
  pages={1900--1908},
  year={2008},
  publisher={Oxford Univ Press},
  sample={12 trans-women (identified as being attracted to women, although the paper chooses to use the term nonhomosexual)},
  conclusion={"Like in female controls the hypothalamus in MFTRs activated with AND, whereas smelling of EST engaged the amygdala and piriform cortex. Male controls, on the other hand, activated the hypothalamus with EST. However, when restricting the volume of interest to the hypothalamus activation was detected in MFTR also with EST, and explorative conjunctional analysis revealed that MFTR shared a hypothalamic cluster with women when smelling AND, and with men when smelling EST. Because the EST effect was limited, MFTR differed significantly only from male controls, and only for EST-AIR and EST-AND. These data suggest a pattern of activation away from the biological sex, occupying an intermediate position with predominantly female-like features. Because our MFTRs were nonhomosexual, the results are unlikely to be an effect of sexual practice. Instead, the data implicate that transsexuality may be associated with sex-atypical physiological responses in specific hypothalamic circuits, possibly as a consequence of a variant neuronal differentiation."},
  citation={Berglund, H., P. Lindstrom, C. Dhejne-Helmy, and I. Savic. "Male-to-Female Transsexuals Show Sex-Atypical Hypothalamus Activation When Smelling Odorous Steroids." Cerebral Cortex 18.8 (2008): 1900-908.},
  fulltext={http://cercor.oxfordjournals.org/content/18/8/1900.long},
  doi={10.1093/cercor/bhm216}
  cited={Hare2009,Luders2009}
}